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This includes information about how to schedule an appointment and a recommended timeframe for follow-up or an INR follow-up test actually scheduled.

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Because most drugs are excreted in human milk, if use of this drug is deemed essential, the patient should stop nursing.

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As a first step, she should have her INR closely monitored (and reduce warfarin dosage).

Observational data, including that derived from clinical trials, may be inappropriate for defining blood pressure targets, since sicker patients may have low blood pressures or, conversely, healthier or more adherent patients may achieve goals more readily.

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Other drugs, such as diuretics, calcium channel blockers, and β-blockers, should be used as additional therapy to further lower blood pressure in patients already treated with ACE inhibitors or ARBs () or as alternate therapy in the rare individual unable to tolerate ACE inhibitors or ARBs.

Although participants who had received active treatment during the main trial had similar levels of diabetes, smoking, and cholesterol, they differed from those who had received placebo in that they had higher blood pressures and concentrations of uric acid at the start of the extension period.

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Eligible subjects were over 55 years of age at entry, had a diagnosis of Type II diabetes mellitus first made at the age of 30 years or older and had an elevated risk of vascular disease.

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An unexpected finding of our trial is the reduction in the risk of death from any cause with active treatment, making HYVET one of the few individual studies of hypertension showing benefits of blood-pressure reduction on mortality.

The efficacy of classifying hypercalciuria on the basis of cause remains controversial and of unproven value in clinical management.

At variance with this, in combination-treated animals blood pressure levels were maintained until the end of the experiment within the 99% confidence interval initially observed in control animals.

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There must be documentation on the signed consent form that during this hospital stay the patient was enrolled in a clinical trial in which patients with the same condition as the measure set were being studied (i.

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It is noteworthy that in the pilot, HYVET participants received either diuretic or ACE inhibitor or placebo, and only diuretics reduced the risk of stroke, whereas ACE inhibitors did not reduce the risk of stroke, despite a similar reduction in BP ().

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Patients who have had excellent blood pressure control for several years, especially if they have lost weight and initiated favorable lifestyle modifications, should be considered for "step-down" of therapy to determine if lower doses or discontinuing of medications is feasible.

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When thiazides lose their hypocalciuric effect, which has been reported to occur, on average, about 2 years after therapy initiation, the use of an alternate regimen for a period of approximately 6 months usually restores the efficacy of the thiazide medication for use in hypercalciuria.

Use of citrates requires attention in order to avoid increasing CaP SS excessively via high urine pH.

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