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Because most drugs are excreted in human milk, if use of this drug is deemed essential, the patient should stop nursing.

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Although participants who had received active treatment during the main trial had similar levels of diabetes, smoking, and cholesterol, they differed from those who had received placebo in that they had higher blood pressures and concentrations of uric acid at the start of the extension period.

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An unexpected finding of our trial is the reduction in the risk of death from any cause with active treatment, making HYVET one of the few individual studies of hypertension showing benefits of blood-pressure reduction on mortality.

The efficacy of classifying hypercalciuria on the basis of cause remains controversial and of unproven value in clinical management.

At variance with this, in combination-treated animals blood pressure levels were maintained until the end of the experiment within the 99% confidence interval initially observed in control animals.

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There must be documentation on the signed consent form that during this hospital stay the patient was enrolled in a clinical trial in which patients with the same condition as the measure set were being studied (i.

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It is noteworthy that in the pilot, HYVET participants received either diuretic or ACE inhibitor or placebo, and only diuretics reduced the risk of stroke, whereas ACE inhibitors did not reduce the risk of stroke, despite a similar reduction in BP ().

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When thiazides lose their hypocalciuric effect, which has been reported to occur, on average, about 2 years after therapy initiation, the use of an alternate regimen for a period of approximately 6 months usually restores the efficacy of the thiazide medication for use in hypercalciuria.

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